Ixazomib Citrate (MLN9708) Analogue
Product Specifications
CAS Number
1201902-80-8
Target
Proteasome
Applications
Proteases
Smiles
B1 (OC (=O) CC (O1) (CC (=O) O) C (=O) O) C (CC (C) C) NC (=O) CNC (=O) C2=C (C=CC (=C2) Cl) Cl
Molecular Formula
C20H23BCl2N2O9
Additionnal Information
Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.
Storage Conditions
2 years -80 in solvent
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