VPLSLYSG

VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), MMP-1 and MMP-2. VPLSLYSG has potential applications in MMP substrates[1][2][3].

Product Specifications

CAS Number

[425632-67-3]

UNSPSC

12352209

Target

MMP

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/vplslysg.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CO)C(NCC(O)=O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H]2N(CCC2)C([C@@H](N)C(C)C)=O)=O)=O)=O)=O

Molecular Formula

C39H62N8O12

Molecular Weight

834.96

References & Citations

[1]Suzuki H, et al. Accurate targeting of activated macrophages based on synergistic activation of functional molecules uptake by scavenger receptor and matrix metalloproteinase. ACS Chem Biol. 2008 Aug 15;3 (8) :471-9. |[2]Patterson J, et al. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials. 2010 Oct;31 (30) :7836-45. |[3]Wieduwild R, et al. Assembling and decorating hyaluronan hydrogels with twin protein superglues to mimic cell-cell interactions. Biomaterials. 2018 Oct;180:253-264.