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Pomalidomide

Product Specifications

CAS Number

19171-19-8

Synonyms

CC-4047

Target

TNF-alpha

Applications

Apoptosis

Smiles

C1CC (=O) NC (=O) C1N2C (=O) C3=C (C2=O) C (=CC=C3) N

Molecular Formula

C13H11N3O4

Additionnal Information

Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN) . Pomalidomide promotes apoptosis and cell cycle arrest.

Storage Conditions

2 years -80 in solvent

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