AZD8055
Product Specifications
CAS Number
1009298-09-2
Target
MTOR
Applications
PI3K/Akt/mTOR
Smiles
CC1COCCN1C2=NC (=NC3=C2C=CC (=N3) C4=CC (=C (C=C4) OC) CO) N5CCOCC5C
Molecular Formula
C25H31N5O4
Additionnal Information
AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.
Storage Conditions
2 years -80 in solvent
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