Vadimezan (DMXAA)
Product Specifications
CAS Number
117570-53-3
Synonyms
ASA404, NSC 640488
Target
VDA
Applications
Angiogenesis
Smiles
CC1=C (C2=C (C=C1) C (=O) C3=CC=CC (=C3O2) CC (=O) O) C
Molecular Formula
C17H14O4
Additionnal Information
Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.
Storage Conditions
2 years -80 in solvent
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