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Vadimezan (DMXAA)

Product Specifications

CAS Number

117570-53-3

Synonyms

ASA404, NSC 640488

Target

VDA

Applications

Angiogenesis

Smiles

CC1=C (C2=C (C=C1) C (=O) C3=CC=CC (=C3O2) CC (=O) O) C

Molecular Formula

C17H14O4

Additionnal Information

Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.

Storage Conditions

2 years -80 in solvent

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