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BIX 02189

Product Specifications

CAS Number

1094614-85-3

Target

MEK

Applications

Protein Tyrosine Kinase

Smiles

CN (C) CC1=CC (=CC=C1) N=C (C2=CC=CC=C2) C3=C (NC4=C3C=CC (=C4) C (=O) N (C) C) O

Molecular Formula

C27H28N4O2

Additionnal Information

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

Storage Conditions

2 years -80 in solvent

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