LY2811376
Product Specifications
CAS Number
1194044-20-6
Target
BACE
Applications
Neuronal Signaling
Smiles
CC1 (CCSC (=N1) N) C2=C (C=C (C (=C2) C3=CN=CN=C3) F) F
Molecular Formula
C15H14F2N4S
Additionnal Information
LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
Storage Conditions
2 years -80 in solvent
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