Quizartinib (AC220)
Product Specifications
CAS Number
950769-58-1
Target
FLT3
Applications
Protein Tyrosine Kinase
Smiles
CC (C) (C) C1=CC (=NO1) NC (=O) NC2=CC=C (C=C2) C3=CN4C5=C (C=C (C=C5) OCCN6CCOCC6) SC4=N3
Molecular Formula
C29H32N6O4S
Additionnal Information
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3 (ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.
Storage Conditions
2 years -80 in solvent
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