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Quizartinib (AC220)

Product Specifications

CAS Number

950769-58-1

Target

FLT3

Applications

Protein Tyrosine Kinase

Smiles

CC (C) (C) C1=CC (=NO1) NC (=O) NC2=CC=C (C=C2) C3=CN4C5=C (C=C (C=C5) OCCN6CCOCC6) SC4=N3

Molecular Formula

C29H32N6O4S

Additionnal Information

Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3 (ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.

Storage Conditions

2 years -80 in solvent

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