Orantinib (SU6668)
Product Specifications
CAS Number
252916-29-3
Synonyms
TSU-68
Target
PDGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (NC (=C1CCC (=O) O) C) C=C2C3=CC=CC=C3NC2=O
Molecular Formula
C18H18N2O3
Additionnal Information
Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.
Storage Conditions
2 years -80 in solvent
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