Staurosporine (STS)
Product Specifications
CAS Number
62996-74-1
Synonyms
AM-2282, Antibiotic AM-2282
Target
PKC
Applications
Cytoskeletal Signaling
Smiles
CC12C (C (CC (O1) N3C4=CC=CC=C4C5=C6C (=C7C8=CC=CC=C8N2C7=C53) CNC6=O) NC) OC
Molecular Formula
C28H26N4O3
Additionnal Information
Staurosporine (STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
Storage Conditions
2 years -80 in solvent
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