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Staurosporine (STS)

Product Specifications

CAS Number

62996-74-1

Synonyms

AM-2282, Antibiotic AM-2282

Target

PKC

Applications

Cytoskeletal Signaling

Smiles

CC12C (C (CC (O1) N3C4=CC=CC=C4C5=C6C (=C7C8=CC=CC=C8N2C7=C53) CNC6=O) NC) OC

Molecular Formula

C28H26N4O3

Additionnal Information

Staurosporine (STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.

Storage Conditions

2 years -80 in solvent

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