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Pelitinib (EKB-569)

Product Specifications

CAS Number

257933-82-7

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CCOC1=C (C=C2C (=C1) N=CC (=C2NC3=CC (=C (C=C3) F) Cl) C#N) NC (=O) C=CCN (C) C

Molecular Formula

C24H23ClFN5O2

Additionnal Information

Pelitinib (EKB-569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. Pelitinib (EKB-569) also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282 nM, 800 nM and 1255 nM, respectively. Phase2.

Storage Conditions

2 years -80 in solvent

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