Ruxolitinib
Product Specifications
CAS Number
941678-49-5
Synonyms
INCB018424
Target
JAK
Applications
Angiogenesis
Smiles
C1CCC (C1) C (CC#N) N2C=C (C=N2) C3=C4C=CNC4=NC=N3
Molecular Formula
C17H18N6
Additionnal Information
Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.
Storage Conditions
2 years -80 in solvent
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