Bafetinib
Product Specifications
CAS Number
859212-16-1
Synonyms
INNO-406, NS-187
Target
Bcr-Abl
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (C=C (C=C1) NC (=O) C2=CC (=C (C=C2) CN3CCC (C3) N (C) C) C (F) (F) F) NC4=NC=CC (=N4) C5=CN=CN=C5
Molecular Formula
C30H31F3N8O
Additionnal Information
Bafetinib is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.
Storage Conditions
2 years -80 in solvent
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