Rigosertib (ON-01910)
Product Specifications
CAS Number
1225497-78-8
Target
PLK
Applications
Cell Cycle
Smiles
COC1=C (C=C (C=C1) CS (=O) (=O) C=CC2=C (C=C (C=C2OC) OC) OC) NCC (=O) [O-].[Na+]
Molecular Formula
C21H24NNaO8S
Additionnal Information
Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.
Storage Conditions
2 years -80 in solvent
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