Ivermectin
Product Specifications
CAS Number
70288-86-7
Synonyms
MK-933
Target
Chloride Channel
Applications
Transmembrane Transporters
Smiles
CCC (C) C1C (CCC2 (O1) CC3CC (O2) CC=C (C (C (C=CC=C4COC5C4 (C (C=C (C5O) C) C (=O) O3) O) C) OC6CC (C (C (O6) C) OC7CC (C (C (O7) C) O) OC) OC) C) C
Molecular Formula
C48H74O14
Additionnal Information
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs) . Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.
Storage Conditions
2 years -80 in solvent
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