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Floxuridine (FUDR)

Product Specifications

CAS Number

50-91-9

Synonyms

NSC 27640, Deoxyfluorouridine

Target

DNA/RNA Synthesis

Applications

Cell Cycle

Smiles

C1C (C (OC1N2C=C (C (=O) NC2=O) F) CO) O

Molecular Formula

C9H11FN2O5

Additionnal Information

Floxuridine (FUDR) is a prodrug that is rapidly catabolized to 5-fluorouracil in vivo. Floxuridine is used to treat various cancers, particularly metastases to the liver. Floxuridine inhibits Poly (ADP-Ribose) polymerase and induces DNA damage and apoptosis. Floxuridine has antiviral effects against HSV and CMV.

Storage Conditions

2 years -80 in solvent

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