Celastrol
Product Specifications
CAS Number
34157-83-0
Synonyms
NSC 70931, Tripterine
Target
Proteasome
Applications
Proteases
Smiles
CC1=C (C (=O) C=C2C1=CC=C3C2 (CCC4 (C3 (CCC5 (C4CC (CC5) (C) C (=O) O) C) C) C) C) O
Molecular Formula
C29H38O4
Additionnal Information
Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.
Storage Conditions
2 years -80 in solvent
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