BX-795

Product Specifications

CAS Number

702675-74-9

Target

IκB/IKK

Applications

NF-κB

Smiles

C1CCN (C1) C (=O) NC2=CC=CC (=C2) NC3=NC=C (C (=N3) NCCCNC (=O) C4=CC=CS4) I

Molecular Formula

C23H26IN7O2S

Additionnal Information

BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.