PD173074
Product Specifications
CAS Number
219580-11-7
Target
FGFR
Applications
Protein Tyrosine Kinase
Smiles
CCN (CC) CCCCNC1=NC2=NC (=C (C=C2C=N1) C3=CC (=CC (=C3) OC) OC) NC (=O) NC (C) (C) C
Molecular Formula
C28H41N7O3
Additionnal Information
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src. PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.
Storage Conditions
2 years -80 in solvent
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