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Topotecan HCl

Product Specifications

CAS Number

119413-54-6

Synonyms

Nogitecan HCl, SKFS 104864A, NSC 609699

Target

Topoisomerase

Applications

DNA Damage/DNA Repair

Smiles

CCC1 (C2=C (COC1=O) C (=O) N3CC4=CC5=C (C=CC (=C5CN (C) C) O) N=C4C3=C2) O.Cl

Molecular Formula

C23H23N3O5.HCl

Additionnal Information

Topotecan HCl is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.

Storage Conditions

2 years -80 in solvent

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