Methotrexate
Product Specifications
CAS Number
59-05-2
Synonyms
NCI-C04671, Amethopterin, CL14377, WR19039
Target
DHFR
Applications
Cell Cycle
Smiles
CN (CC1=CN=C2C (=N1) C (=NC (=N2) N) N) C3=CC=C (C=C3) C (=O) NC (CCC (=O) O) C (=O) O
Molecular Formula
C20H22N8O5
Additionnal Information
Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase (DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
Storage Conditions
3 years -20°C (in the dark) powder1 year -80°C (in the dark) in solvent
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