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Tivozanib

Product Specifications

CAS Number

475108-18-0

Synonyms

AV-951, KRN-951

Target

C-Kit

Applications

Protein Tyrosine Kinase

Smiles

CC1=CC (=NO1) NC (=O) NC2=C (C=C (C=C2) OC3=C4C=C (C (=CC4=NC=C3) OC) OC) Cl

Molecular Formula

C22H19ClN4O5

Additionnal Information

Tivozanib is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R. Phase 3.

Storage Conditions

2 years -80 in solvent

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