Aprepitant
Product Specifications
CAS Number
170729-80-3
Synonyms
MK-0869, L-754030
Target
HIV
Applications
Microbiology
Smiles
CC (C1=CC (=CC (=C1) C (F) (F) F) C (F) (F) F) OC2C (N (CCO2) CC3=NNC (=O) N3) C4=CC=C (C=C4) F
Molecular Formula
C23H21F7N4O3
Additionnal Information
Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.
Storage Conditions
2 years -80 in solvent
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