What is the catalog number for ENMD-2076?

The catalog number for ENMD-2076 is C07590-10mM/1mL.

What sizes are available for ENMD-2076?

ENMD-2076 is available in the following size(s): 10 mM/1mL.

Is ENMD-2076 in stock?

ENMD-2076 is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for ENMD-2076?

ENMD-2076 is requires dry ice shipping.

ENMD-2076

Product Specifications

CAS Number

934353-76-1

Target

Aurora Kinase

Applications

Cell Cycle

Smiles

CC1=CC (=NN1) NC2=CC (=NC (=N2) C=CC3=CC=CC=C3) N4CCN (CC4) C

Molecular Formula

C21H25N7

Additionnal Information

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.