Regorafenib
Product Specifications
CAS Number
755037-03-7
Synonyms
Fluoro-Sorafenib, BAY 73-4506
Target
C-RET
Applications
Protein Tyrosine Kinase
Smiles
CNC (=O) C1=NC=CC (=C1) OC2=CC (=C (C=C2) NC (=O) NC3=CC (=C (C=C3) Cl) C (F) (F) F) F
Molecular Formula
C21H15ClF4N4O3
Additionnal Information
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit (c-Kit), RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively. Regorafenib induces autophagy.
Storage Conditions
2 years -80 in solvent
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