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WZ3146

Product Specifications

CAS Number

1214265-56-1

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CN1CCN (CC1) C2=CC=C (C=C2) NC3=NC=C (C (=N3) OC4=CC=CC (=C4) NC (=O) C=C) Cl

Molecular Formula

C24H25ClN6O2

Additionnal Information

WZ3146 is a mutant-selective irreversible inhibitor of EGFR (L858R) and EGFR (E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I) .

Storage Conditions

2 years -80 in solvent

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