Tanespimycin (17-AAG)
Product Specifications
CAS Number
75747-14-7
Synonyms
CP127374, NSC-330507, KOS 953
Target
HSP (HSP90)
Applications
Cytoskeletal Signaling
Smiles
CC1CC (C (C (C=C (C (C (C=CC=C (C (=O) NC2=CC (=O) C (=C (C1) C2=O) NCC=C) C) OC) OC (=O) N) C) C) O) OC
Molecular Formula
C31H43N3O8
Additionnal Information
Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.
Storage Conditions
2 years -80 in solvent
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