Alisertib (MLN8237)
Product Specifications
CAS Number
1028486-01-2
Target
Aurora Kinase
Applications
Cell Cycle
Smiles
COC1=C (C (=CC=C1) F) C2=NCC3=CN=C (N=C3C4=C2C=C (C=C4) Cl) NC5=CC (=C (C=C5) C (=O) O) OC
Molecular Formula
C27H20ClFN4O4
Additionnal Information
Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.
Storage Conditions
2 years -80 in solvent
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