Sepantronium Bromide (YM155)

Product Specifications

CAS Number

781661-94-7

Target

Survivin

Applications

Apoptosis

Smiles

CC1=[N+] (C2=C (N1CCOC) C (=O) C3=CC=CC=C3C2=O) CC4=NC=CN=C4.[Br-]

Molecular Formula

C20H19BrN4O3

Additionnal Information

Sepantronium Bromide (YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.