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XL147 analogue

Product Specifications

CAS Number

956958-53-5

Synonyms

SAR245408

Target

PI3K

Applications

PI3K/Akt/mTOR

Smiles

CC1=CC=C (C=C1) S (=O) (=O) NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4

Molecular Formula

C21H16N6O2S2

Additionnal Information

XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. XL147 analogue induces apoptosis. Phase 1/2.

Storage Conditions

2 years -80 in solvent

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