Danusertib (PHA-739358)
Product Specifications
CAS Number
827318-97-8
Target
Aurora Kinase
Applications
Cell Cycle
Smiles
CN1CCN (CC1) C2=CC=C (C=C2) C (=O) NC3=NNC4=C3CN (C4) C (=O) C (C5=CC=CC=C5) OC
Molecular Formula
C26H30N6O3
Additionnal Information
Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
DJB57449-01 250 mg
3-[4,6-Dimethyl-1- (propan-2-yl) -1H-pyrazolo[3,4-b]pyridin-5-yl]propanoic acid
Sign In for Pricing
View Details