LY294002
Product Specifications
CAS Number
154447-36-6
Synonyms
SF 1101, NSC 697286
Target
Autophagy
Applications
Autophagy
Smiles
C1COCCN1C2=CC (=O) C3=C (O2) C (=CC=C3) C4=CC=CC=C4
Molecular Formula
C19H17NO3
Additionnal Information
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
Storage Conditions
2 years -80 in solvent
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