LY294002

Product Specifications

CAS Number

154447-36-6

Synonyms

SF 1101, NSC 697286

Target

Autophagy

Applications

Autophagy

Smiles

C1COCCN1C2=CC (=O) C3=C (O2) C (=CC=C3) C4=CC=CC=C4

Molecular Formula

C19H17NO3

Additionnal Information

LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.