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ZM 447439

Product Specifications

CAS Number

331771-20-1

Target

Aurora Kinase

Applications

Cell Cycle

Smiles

COC1=C (C=C2C (=C1) C (=NC=N2) NC3=CC=C (C=C3) NC (=O) C4=CC=CC=C4) OCCCN5CCOCC5

Molecular Formula

C29H31N5O4

Additionnal Information

ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.

Storage Conditions

2 years -80 in solvent

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