Linsitinib (OSI-906)
Product Specifications
CAS Number
867160-71-2
Target
IGF-1R
Applications
Protein Tyrosine Kinase
Smiles
CC1 (CC (C1) C2=NC (=C3N2C=CN=C3N) C4=CC5=C (C=C4) C=CC (=N5) C6=CC=CC=C6) O
Molecular Formula
C26H23N5O
Additionnal Information
Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.
Storage Conditions
2 years -80 in solvent
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