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Linsitinib (OSI-906)

Product Specifications

CAS Number

867160-71-2

Target

IGF-1R

Applications

Protein Tyrosine Kinase

Smiles

CC1 (CC (C1) C2=NC (=C3N2C=CN=C3N) C4=CC5=C (C=C4) C=CC (=N5) C6=CC=CC=C6) O

Molecular Formula

C26H23N5O

Additionnal Information

Linsitinib (OSI-906) is a selective inhibitor of IGF-1R with IC50 of 35 nM in cell-free assays; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.

Storage Conditions

2 years -80 in solvent

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