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Refametinib (RDEA119)

Product Specifications

CAS Number

923032-37-5

Synonyms

Bay 86-9766

Target

MEK

Applications

Protein Tyrosine Kinase

Smiles

COC1=CC (=C (C (=C1NS (=O) (=O) C2 (CC2) CC (CO) O) NC3=C (C=C (C=C3) I) F) F) F

Molecular Formula

C19H20F3IN2O5S

Additionnal Information

Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

Storage Conditions

2 years -80 in solvent

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