Luminespib (NVP-AUY922)
Product Specifications
CAS Number
747412-49-3
Synonyms
AUY-922, VER-52296
Target
HSP (HSP90)
Applications
Cytoskeletal Signaling
Smiles
CCNC (=O) C1=NOC (=C1C2=CC=C (C=C2) CN3CCOCC3) C4=CC (=C (C=C4O) O) C (C) C
Molecular Formula
C26H31N3O5
Additionnal Information
Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
Storage Conditions
2 years -80 in solvent
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