Crizotinib
Product Specifications
CAS Number
877399-52-5
Synonyms
PF-02341066
Target
ALK
Applications
Protein Tyrosine Kinase
Smiles
CC (C1=C (C=CC (=C1Cl) F) Cl) OC2=C (N=CC (=C2) C3=CN (N=C3) C4CCNCC4) N
Molecular Formula
C21H22Cl2FN5O
Additionnal Information
Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
Storage Conditions
2 years -80 in solvent
More Discoveries
Explore Other Products
Browse additional items from our catalog
B2674-75A 100 µg
Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT)
Sign In for Pricing
View Details 
