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Pictilisib (GDC-0941)

Product Specifications

CAS Number

957054-30-7

Synonyms

RG7321

Target

PI3K

Applications

PI3K/Akt/mTOR

Smiles

CS (=O) (=O) N1CCN (CC1) CC2=CC3=C (S2) C (=NC (=N3) C4=C5C=NNC5=CC=C4) N6CCOCC6

Molecular Formula

C23H27N7O3S2

Additionnal Information

Pictilisib (GDC-0941, RG7321) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold) . Pictilisib (GDC-0941) induces autophagy and apoptosis. Phase 2.

Storage Conditions

2 years -80 in solvent

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