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Olaparib (AZD2281)

Product Specifications

CAS Number

763113-22-0

Synonyms

Ku-0059436

Target

PARP

Applications

DNA Damage/DNA Repair

Smiles

C1CC1C (=O) N2CCN (CC2) C (=O) C3=C (C=CC (=C3) CC4=NNC (=O) C5=CC=CC=C54) F

Molecular Formula

C24H23FN4O3

Additionnal Information

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.

Storage Conditions

2 years -80 in solvent

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