AC480 (BMS-599626)
Product Specifications
CAS Number
714971-09-2
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1=C2C (=NC=NN2C=C1NC (=O) OCC3COCCN3) NC4=CC5=C (C=C4) N (N=C5) CC6=CC (=CC=C6) F
Molecular Formula
C27H27FN8O3
Additionnal Information
AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.
Storage Conditions
2 years -80 in solvent
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