What is the catalog number for Tozasertib (VX-680)?

The catalog number for Tozasertib (VX-680) is C16078-100mg.

What sizes are available for Tozasertib (VX-680)?

Tozasertib (VX-680) is available in the following size(s): 100 mg.

Is Tozasertib (VX-680) in stock?

Tozasertib (VX-680) is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for Tozasertib (VX-680)?

Tozasertib (VX-680) is requires dry ice shipping.

Tozasertib (VX-680)

Product Specifications

CAS Number

639089-54-6

Synonyms

MK-0457

Target

Aurora Kinase

Applications

Cell Cycle

Smiles

CC1=CC (=NN1) NC2=CC (=NC (=N2) SC3=CC=C (C=C3) NC (=O) C4CC4) N5CCN (CC5) C

Molecular Formula

C23H28N8OS

Additionnal Information

Tozasertib (VX-680) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.