Sorafenib tosylate
Product Specifications
CAS Number
475207-59-1
Synonyms
BAY 43-9006 tosylate, NSC-724772 tosylate
Target
PDGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC=C (C=C1) S (=O) (=O) O.CNC (=O) C1=NC=CC (=C1) OC2=CC=C (C=C2) NC (=O) NC3=CC (=C (C=C3) Cl) C (F) (F) F
Molecular Formula
C21H16ClF3N4O3.C7H8O3S
Additionnal Information
Sorafenib tosylate is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Storage Conditions
2 years -80 in solvent
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