Lenalidomide
Product Specifications
CAS Number
191732-72-6
Synonyms
CC-5013
Target
TNF-alpha
Applications
Apoptosis
Smiles
C1CC (=O) NC (=O) C1N2CC3=C (C2=O) C=CC=C3N
Molecular Formula
C13H13N3O3
Additionnal Information
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E45H01423-2 20 µg
TSEN2 (NM_001145394) Human Over-expression Lysate
Sign In for Pricing
View Details 
78626-2 2x 500 µL
Spike (BA.2, Omicron Variant) (SARS-CoV-2) Pseudotyped Lentivirus (eGFP Reporter)
Sign In for Pricing
View Details ABP-S-04283 5 Plates
Bovine BDNF Matched Antibody Pair Set [ABP-S-04283]
Sign In for Pricing
View Details