Gefitinib
Product Specifications
CAS Number
184475-35-2
Synonyms
ZD1839
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
COC1=C (C=C2C (=C1) N=CN=C2NC3=CC (=C (C=C3) F) Cl) OCCCN4CCOCC4
Molecular Formula
C22H24ClFN4O3
Additionnal Information
Gefitinib is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.
Storage Conditions
2 years -80 in solvent
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