Ridaforolimus (Deforolimus, MK-8669)
Product Specifications
CAS Number
572924-54-0
Synonyms
AP23573
Target
MTOR
Applications
PI3K/Akt/mTOR
Smiles
CC1CCC2CC (C (=CC=CC=CC (CC (C (=O) C (C (C (=CC (C (=O) CC (OC (=O) C3CCCCN3C (=O) C (=O) C1 (O2) O) C (C) CC4CCC (C (C4) OC) OP (=O) (C) C) C) C) O) OC) C) C) C) OC
Molecular Formula
C53H84NO14P
Additionnal Information
Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. Phase 3.
Storage Conditions
2 years -80 in solvent
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